Download Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: by Marcel Gielen, Edward R. T. Tiekink PDF

By Marcel Gielen, Edward R. T. Tiekink

There are an unbelievable quantity and diversity of roles that metals play in modern drugs. This publication includes info at the medicinal makes use of of inorganics, that's, of components corresponding to boron, lithium, selenium, to call a number of, in addition to metal-containing species.

based on the suggestion that fit mammals depend upon (bio-essential) metals for the conventional functioning of roughly a 3rd in their proteins and enzymes, a lot of medicines are metal-based and substantial attempt is being dedicated to constructing either moment- and third-generation medicines in addition to producing novel metal-based medicinal drugs. whereas there's no doubt that there's an emphasis on 'Metallotherapeutics' during the quantity, using metals in drugs isn't really constrained to metal-based medications. the next also are lined:

  • non-invasive radiopharmaceuticals
  • Magnetic Resonance Imaging (MRI)
  • mineral supplementations

From the foregoing and, extra importantly, from the contents of many of the Chapters, the reader will achieve an appreciation of the very genuine function metal-based medications play in smooth drugs and of the huge attempt being dedicated to the advance of novel complexes with larger efficacy as healing and diagnostic brokers.

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Additional resources for Metallotherapeutic Drugs and Metal-Based Diagnostic Agents: The Use of Metals in Medicine

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J. Neurochem. 1999; 72: 879. 68. Nonaka S, Chuang DM. Neuroreport. 1998; 9: 2081. 2 5B Boron Compounds as Therapeutic Drugs Geeta Rana, Kamesh Vyakaranam, John A. Maguire and Narayan S. Hosmane Boron analogues of a variety of biologically important molecules have been found to play an increasingly important role in the areas of pharmacology, medicine, biochemistry and nutrition. Bearing close structural resemblance to their natural organic counterparts, the boron analogues exhibit potent biological activities.

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Chemotherapeutic alkylating agents are electrophiles that can be covalently incorporated into tumor DNA and, as a result, interfere with tumor replication.

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