By Francisco Sobrino, Esteban Domingo
The surprise following the hot outbreak of foot-and-mouth ailment (FMD) within the united kingdom dispelled the idea that this illness used to be completely below keep watch over and will be forgotten. FMD proved to be a plague ailment in lots of international locations and keeps to pose a huge hazard to animal well-being all over the world. the advance of greater and socially appropriate prognosis and keep an eye on measures is vital to successfully strive against this devastating virus. Foot and Mouth illness: present views advantages researchers by way of featuring the newest advancements caused by the upsurge in facts bearing on this sickness. Interdisciplinary in its strategy, this ebook deals the 1st coherent photo of rising suggestions for prognosis and keep watch over. With contributions from revered FMD researchers all over the world, this quantity offers finished insurance of the complete spectrum of FMD matters. issues contain genome association, translation and replication of FMD virus RNA, proteinases, virus debris, medical indicators of FMD, and lots more and plenty extra. This e-book can provide crucial info for everybody with an curiosity in FMD, reminiscent of virologists, molecular biologists, biotechnologists, veterinarians, and pharmaceutical and biotech researchers.
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Extra resources for Foot and Mouth Disease: Current Perspectives
A binding site for PCBP2 within the FMDV IRES has been mapped to domain 3 (Stassinopoulos and Belsham, 2001), consistent with the presence of the conserved ACCC loop. , 1999; Stassinopoulos and Belsham, 2001). , 1996). These results strongly suggested that formation of a helical structure around positions 88 and 297 of the FMDV IRES is needed for efficient internal initiation of translation. Computer-assisted secondary structure prediction of the whole FMDV IRES sequence represents the base of domain 3 as a long stem interrupted with bulges (Figure 2).
Many of the processing intermediates and mature proteins that are generated by the action of virus-encoded proteases on the polyprotein precursor are depicted. Each of these features is discussed within the text. Copyright © 2004 By Horizon Bioscience Be/sham and Martinez-Sa/as 211 The 5' untranslated region (UTR) of the FMDV RNA is about 1300 nt in length. This is much longer than the 5'UTRs of most cellular mRNAs (typically 50-100 nt). The large open reading frame within the RNA encodes a polyprotein.
2001). Thus, a similar role for this motif within IRES elements is Copyright © 2004 By Horizon Bioscience Be/sham and Martinez-Sa/as 271 3 (I) 5 (L) 1 (G) Figure 2. FMDV IRES structural organization. A representation of the secondary structure of the FMDV IRES generated by the M-Fold program of the GCG package is shown. The positions of residues cited in the text are indicated with numbers. An unused AUG triplet located 8 nt upstream of the first functional AUG is underlined. The sites on the IRES that interact with eIF4G, eIF4B, eIF3 and PTB are described in the text.