Download Ciba Foundation Symposium 81 - Peptides of the Pars PDF

Content:
Chapter 1 Chairman's creation (pages 1–2): G.M. Besser
Chapter 2 The Intermediate Lobe of the Pituitary Gland: creation and historical past (pages 3–12): Aaron B. Lerner
Chapter three constitution and Chemistry of the Peptide Hormones of the Intermediate Lobe (pages 13–31): Alex N. Eberle
Chapter four comparability of Rat Anterior and Intermediate Pituitary in Tissue tradition: Corticotropin (ACTH) and ??Endorphin (pages 32–54): Richard E. Mains and Betty A. Eipper
Chapter five Processing, Turnover and free up of Corticotropins, Endorphins and Melanotropin within the Toad Pituitary Intermediate Lobe (pages 55–78): Y. Peng Loh
Chapter 6 ??Endorphin?Related Peptides within the Pituitary Gland: Isolation, identity and Distribution (pages 79–100): D. G. Smyth, S. Zakarian, J. F. W. Deakin and D. E. Massey
Chapter 7 effective constitution and Cytochemistry of the Mammalian Pars Intermedia (pages 101–127): M. E. Stoeckel, G. Schmitt and A. Porte
Chapter eight Distribution, Subcellular Localization and identification of Immunoreactive ??Melanotropin within the Pituitary Gland and mind (pages 128–140): I. C. Porter, F. J. H. Tilders, A. Barnea and C. R. Parker
Chapter nine Nature and regulate of Peptide unlock from the Pars Intermedia (pages 141–165): Sue Jackson, J. wish, F. Estivariz and P. J. Lowry
Chapter 10 organic function of the Pars Intermedia in decrease Vertebrates (pages 166–179): Bridget I. Baker
Chapter eleven The Pars Intermedia and the Fetal Pituitary?Adrenal Axis (pages 180–195): R.E. Silman, Cathy road, Diane Holland, T. Chard, J. Falconer and J. S. Robinson
Chapter 12 services of ??Melanotropin and different Opiomelanocortin Peptides in Labour, Intrauterine development and mind improvement (pages 196–223): D. F. Swaab and J. T. Martin
Chapter thirteen Pars Intermedia Peptides: stories in grownup people (pages 224–243): Sally J. Ratter, Lorraine McLoughlin, Glenda Gillies, Vicky Clement?Jones, J. desire and Lesley H. Rees
Chapter 14 organic activities of Melanocyte?Stimulating Hormone (pages 244–262): Mac E. Hadley, Christopher B. Heward, Victor I. Hruby, Tomi okay. Sawyer and younger C. S. Yang
Chapter 15 ? ?Melanotropin and mind functionality (pages 263–276): Jan M. Van Ree, Bela Bohus, Katharina M. Csontos, Willem Hendrik Gispen, Henk M. Greven, Frans P. Nijkamp, Fred A. Opmeer, Guus (A.) A. De Rotte, Tjeerd B. Van Wimersma Greidanus, Albert Witter and David De Wed
Chapter sixteen Melanocyte?Stimulating Hormone and Adaptive Behaviour (pages 277–294): Tjeerd B. Van Wimersma Greidanus, Guus (A.) A. De Rotte, Anthony J. Thody and Alex N. Eberle
Chapter 17 Chairman's last comments (pages 299–300): G.M. Besser

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2,6 ring-’H]phenylalanine (150pM; 66 Ci/mmole; New England Nuclear) was present for the 20 h immediately preceding extraction. Extracts were immunoprecipitated with &endorphin antiserum Melinda (Eipper & Mains 1978a); pendorphin-sized material was obtained by gel fdtration; samples were dissolved in 50% acetic acid and analysed on SP-Sephadex. Aliquots of fractions were analysed by liquid scintillation counting; recovery of radioactivity was greater than 90% in each case. 84 ml and the column profiles have been adjusted to take this difference into account.

220, Drs. W. Rittel and P. A. Desmlles (CIBA-GEIGY) for hACTH(17-39) and hACTH(1-39), and Drs. R. Dores and S. J. Watson for instruction in immunohistochemical methods. Can J Biochem 57: 11 11-1 121 Eipper BA, Mains RE 1978a Analysis of the common precursor to corticotropin and endorphin. J Biol Chem 25357324744 RAT ANTERIOR AND INTERMEDIATE PITUITARY IN CULTURE 47 Eipper BA, Mains RE 1978b Existence of a common precursor to ACTH and endorphin in the anterior and intermediate lobes of the rat pituitary.

Smyfh: I have been applying these concepts myself to endorphins (Smyth 1980), CHEMISTRY OF INTERMEDIATELOBE PEPTIDES 29 but I think the approach is a little unsophisticated. If we apply the message and address principle to an enzyme, for example, we see that it has an active site comprising as few as five amino acid residues, which one might call the message region, but the remainder of the enzyme sequence exerts a powerful influence on activity as a consequence of three-dimensional interactions.

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