By Dr. Keya Chaudhuri, Prof. S. N. Chatterjee (eds.)
Vibrio cholerae, the causative organism of the disorder Cholera, colonizes the small gut and produces numerous various pollution between which the enterotoxin, or extra well known as cholera toxin (CT), occurs to be the main virulence determinant that's answerable for the diarrheal syndrome. This publication offers for the 1st time complete and up to date information regarding all of the pollution of Vibrio cholerae, their actual and chemical constructions, their biosynthesis and its genetic legislation, their body structure, the molecular biology in their interactions with the host in addition to their function within the improvement of a suitable and potent cholera vaccine. It additionally deals appropriate and precious heritage info at the simple biology of the Vibrio cholerae cellphone and cholera bacteriophages.
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Extra resources for Cholera Toxins
This technique is believed to be useful when investigating the origins of new outbreaks of disease. Zymovar analysis or MEE is applied here to investigate the genetic variation of V. cholerae strains and to characterize strains or groups of strains of medical and epidemiological interest. Fourteen loci were analyzed in 171 strains of non-O1 non-O139, 32 classical and 61 El Tor from America, Africa, Europe, and Asia (Freitas et al. 2002). 339. It is shown that the same O antigen (both O1 and nonO1) may be present in several genetically diverse (different zymovars) strains.
1997). V. cholerae O22, unlike O139, lacks a CPS but possesses an O-PS structure comparable to that of V. cholerae O139. The similarity in the O-PS structures of the serogroups O139 and O22 can be elaborated further. Both serogroups contain the same trisaccharide GlcNAcGalA-QuiNAc, and in both cases the N-acetylglucosamine residue is disubstituted at the 3- and 4-positions. Further, rare terminal 3,6-dideoxy-L-xylo hexose (colitose) residues are present in both the O22 and O139 serogroups. To elaborate on the differences in the O-PS structures of these two serogroups, it may be noted that in O22, the N-acetylglucosamine has the α-configuration and not the β-configuration observed previously for O139.
Mekalanos and also from the Editor of Science) basis of their serological properties, plaque morphology, thermal death points, etc. Electron microscopy revealed significant characteristics of these phages, and the phages belonging to any of Mukerjee’s four groups had distinct morphologies (Fig. 7) (Chatterjee et al. 1965, Das and Chatterjee 1966b,Maiti and Chatterjee 1971, Chatterjee and Maiti 1984). This was practically the first indication of the fact that electron microscopic morphology can be used as an important parameter in phage or viral taxonomy, which was subsequently utilized extensively for the classification of viruses by the International Committee for the Taxonomy of Viruses (ICTV).