Download Cell Communication in Nervous and Immune System by Eckart D. Gundelfinger, Constanze Seidenbecher, Burkhart PDF

By Eckart D. Gundelfinger, Constanze Seidenbecher, Burkhart Schraven

At first look, the fearful and immune structures seem very diversified. although, either structures have built mechanisms for reminiscence formation – notwithstanding of really various caliber and importance for the organism. One remarkable instance is that either platforms shape and converse through synapses armed with related units of proteins. This choice of stories, contributed via across the world famous immunologists and molecular and mobile neurobiologists, places aspect via part mobile verbal exchange units and signaling mechanisms within the immune and worried structures and discusses mechanisms of interplay among the 2 platforms, the importance of which has just recently been absolutely appreciated.

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2002). Clusters of α1 are found to co-localize with gephyrin, whereas diffuse α1 staining indicates that a considerable amount of α1 containing receptors are found extrasynaptically (Brunig et al. 2002). The subcellular targeting of α3 containing receptors appears to be dependent on the type of cell where it is expressed. In a subset of hippocampal cells, characterized by a round cell body and numerous short dendrites, α3 staining is generally diffuse and with no gephyrin co-localization although in the AIS large clusters can also be found (Brunig et al.

An interaction between β subunits and the endosomal protein HAP1 is thought to facilitate the recycling of receptors back to the plasma membrane receptor (Kittler et al. 2005). Interestingly, this region includes the major sites of serine phosphorylation within β subunits and will only bind AP2 when in a dephosphorylated state (Kittler et al. 2005). These results provide direct evidence for the importance of phosphorylation in regulating receptor stability at the cell surface.

Analysis of both α- and β-dystroglycan localization in cultured hippocampal neurons revealed that, like dystrophin, dystroglycan is found at a subset of GABAergic terminals, although this co-localization was only evident in late stages of development (Levi et al. 2002). In cultured hippocampal neurons from dystroglycan conditional knockout mice, there was no evidence of dystophin accumulation yet GABAA receptor and gephyrin synaptic accumulation was unaltered (Levi et al. 2002). Together, these results indicate that the DGC is not required for GABAA receptor clustering, but might play a stabilizing role for the receptor at inhibitory synapses.

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