By Stanley Hoang M.D., Henry Jung M.D., Tonya Bliss Ph.D., Gary Steinberg M.D., Ph.D. (auth.), Jukka Jolkkonen, Piotr Walczak (eds.)
Stroke is still one of many major explanations of dying and incapacity world wide. whereas powerful remedy for stroke restoration is still an unmet desire. a lot wish and gives you are put on cell-based remedies. the purpose of this publication is to supply centred but entire experiences at the present country of cell-based methods within the therapy of stroke. the themes lined contain experimental info on sensible consequence after intravascular and intracerebral supply of cells in stroke animals, by way of translational chapters that allows you to depend seriously at the use of other imaging modalities within the monitoring of cells. The final and so much hard half will describe the early section of scientific experiences, supplying directions for destiny study and medical functions. sincerely and concisely written, this article is going to be an invaluable source for neurologists, radiologists, and neuroscientists attracted to phone transplantation as a healing technique for stroke patients.
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Additional info for Cell-Based Therapies in Stroke
Neurosci Lett 316:9–12 Tonder N, Sorensen T, Zimmer J, Jorgensen MB, Johansen FF et al (1989) Neural grafting to ischemic lesions of the adult rat hippocampus. Exp Brain Res 74:512–526 Trojanowski JQ, Mantione JR, Lee JH, Seid DP, You T et al (1993) Neurons derived from a human teratocarcinoma cell line establish molecular and structural polarity following transplantation into the rodent brain. Exp Neurol 122:283–294 Vendrame M, Cassady CJ, Newcomb J, Butler T, Pennypacker KR et al (2004) Infusion of human umbilical cord blood cells in a rat model of stroke dose-dependently rescues behavioral deficits and reduces infarct volume.
As research accumulates, it appears as if stem cells can be obtained from teeth during various stages of their development (Miura et al. 2003). Teeth-derived stem cells have also demonstrated neurogenic potential (Zhang et al. 2009), possibly with greater aptitude than bone marrow-derived cells (Karaoz et al. 2011). 14 Embryonic Stem Cells The preceding sections discussed adult stem cells. Another equally potential cell source for transplantation therapy in stroke is embryonic stem (ES) cells. Arguably, ES cells have been used as the yardstick of “stemness” properties, allowing an indefinite supply of stem cells which give rise to cells derived from all three germ layers.
2004). Those animals that were injected with microglia had significantly more neurons surviving in lesioned cortex than did vehicle-treated controls. 2 Intracisternal When NSCs derived from subventricular zone were injected, MRI was used to track ferromagnetic-labeled NSCs from young adult rat when they were injected into the cisterna magna 48 h after MCAO (Zhang et al. 2003). Fully 85 % of the MRI signal was observed in the ischemic striatum; almost 6,000 labeled cells of the 100,000 transplanted were present by 35 days post transplant.