Download Bioprobes: Biochemical Tools for Investigating Cell Function by Hiroyuki Osada (auth.), Hiroyuki Osada (eds.) PDF

By Hiroyuki Osada (auth.), Hiroyuki Osada (eds.)

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The kinase activity of these CDKs are regulated by a variety of checkpoint mechanisms following mitogen stimulation and damage to DNA and other cellular architectures. 1 Cyclin-Dependent Kinase Cyclin-dependent kinases (CDKs) act as the engine that drives the cell cycle. The proper sequence of cell cycle events is governed by a control system consisting of CDKs and their regulatory subunits, cyclins. The first CDK called Cdc2 was identified as the product of a gene of Schizosaccharomyces pombe that complements the ts mutation of a fission yeast cell division cycle (cdc) mutantcdc2.

The use of affinity columns containing the N-terminal activation domain of c-Jun led to identification of at least two kinase activities, 46 and 55 kDa in size, which bind to this region and phosphorylate it on serines 63 and 73. The kinases were named JNKs, and were also independently identified as cycloheximide activated protein kinases, SAPKs. As mentioned above, the JNK subfamily including JNKl, JNK2, and JNK3 (also known as SAPKa, SAPK/3, and SAPKy) belongs to the MAPK superfamily protein kinases [17].

Mol Cell Bioi 19: 1346--1358 126. Gorospe M, Liu Y, Xu Q, Chrest FJ, Holbrook NJ (1996) Inhibition of GI cyclindependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2. Mol Cell Bioi 16:762-770 127. Fenteany G, Standaert RF, Lane WS, Choi S, Corey EJ, Schreiber SL(1995) Inhibition of proteasome activities and subunit-specific amino-terminal threonine modification by lactacystin. Science 268:726--731 128. Lane DP (1992) Cancer. p53, guardian of the genome.

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