By Elizabeth Fiona McInnes BVSc MRCVS PhD FRCPath
Background Lesions in Laboratory Animals can be a useful relief to pathologists wanting to acknowledge historical past and incidental lesions whereas interpreting slides taken from laboratory animals in acute and persistent toxicity stories, or whereas analyzing unique species in a diagnostic laboratory. It supplies transparent descriptions and illustrations of nearly all of heritage lesions more likely to be encountered. a few of the lesions coated are strange and will be unsuitable for treatment-related findings in preclinical toxicity studies.
The Atlas has been ready with contributions from skilled toxicological pathologists who're experts in all of the laboratory animal species lined and who've released greatly in those areas.
- over six hundred high-definition, most advantageous colour photos of history lesions present in rats, mice, canine, minipigs, non-human primates, hamsters, guinea pigs and rabbits
- a separate bankruptcy on lesions within the reproductive platforms of all laboratory animals written through Dr Dianne Creasy, a global professional on testicular lesions in laboratory animals
- a bankruptcy on universal artifacts that could be saw in histological glass slides
- extensive references to every lesion described
- aging lesions encountered in all laboratory animal species, quite in rats in mice that are used for carcinogenicity studies
Read Online or Download Background Lesions in Laboratory Animals. A Color Atlas PDF
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Additional resources for Background Lesions in Laboratory Animals. A Color Atlas
17) (Colby et al 2007). 17 Dilated subpleural lymphatics. ×100. 14 Fibrosing alveolitis at higher magnification characterized by fibrosis of the alveolar septae with a hyperplastic epithelial lining with or without an associated inflammatory reaction. ×100.
9 Hyaline deposits in the germinal centre of a lymphoid follicle. ×100. 12 Mineralization of peribronchiolar smooth muscle. Image courtesy of DJ Lewis. ×200. Beagle dog Fibrosing alveolitis, also known as segmental fibrosis, may be seen macroscopically as pale, white, focal thickenings of the pleural surface, often at the edges of the lung lobes. 14) these lesions are wedgeshaped areas of alveolar fibrosis extending into the lung parenchyma from the pleura, with associated epithelial hyperplasia and occasional small numbers of chronic inflammatory cells (Glaister 1986, Hahn & Dagle 2001).
Et al. ), Pathology of the Fischer rat. Academic Press, San Diego, pp. 71–92. , 2004. Androgen and estrogen receptors expression in the rat exorbital lacrimal gland in relation to “harderianization”. J. Exp. Zool. 301A, 297–306. , 2007. The rat. C. ), Animal models in toxicology, second ed. Taylor & Francis, Boca Raton, pp. 147–217. , 2009. Eosinophilic inclusions in rat Clara cells and the effect of an inhaled corticosteroid. Toxicol. Pathol. 37, 315–323. , 1969. Melanotic lesions of the eye in August hooded rats induced by urethan or N-hydroxyurethan given during the neonatal period: a histopathological study.